I'm from the midwest and have driven alot in Europe. It seems to be about the same as here........except......
1. The people tend to drive like they are fucking NUTS!
2. The road signs generally suck. Netherlands signs are better than other countries.
3. An excellent road map is a must - any good filling station will have a big book-type. (ie.If a sign says dusseldorf is a right turn it doesn't mean dusseldorf is actually to the right it just means that's A means of getting there could be twice farther than if you took the next road but yes it will eventually lead you there.
4. Diesel is cheaper than gas but still more expensive than here.
5. It's always a rip-off to park(Last time I parked overnight in Amsterdam it was expensive as hell.)
But......your still doing the right thing. Just go a little slower and be safe. Remember western Europe is just as civilized as here...of course they have good road cleaning. Now driving in Eastern Europe is sort of like playing Russian roulet(no pun intended).
I recommend getting a diesel stick shift car....I like what they call the "5 person people mover". I also suggest you try
www.novacarhire.com this place kicks ass!! insurance is included and they are always the cheapest. They play middleman but you always get your car at a top-notch company...ie alamo,hertz,sixt,etc..
Just relax and enjoy....you'll see alot more and more conveniently from a car than you will a train. Where do you plan to go?......just curious.